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| 1446 |
| | | Portugal claims ownership of the region of Guinea, subsequently the centre of their slave trade on the west African coast | |
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| 1466 |
| | | The Portuguese settlers on the Cape Verde islands are granted a monopoly on the new slave trade | |
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| c. 1550 |
| | | Africans, bought in the Portuguese trading posts of west Africa, are shipped across the Atlantic as slaves | |
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| 1655 |
| | | The British, settling in Jamaica, soon turn the island into the major slave market of the West Indies | |
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| 1657 |
| | | The Dutch in South Africa purchase slaves to do domestic and agricultural work | |
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| 1688 |
| | | Aphra Behn's novel Oroonoko makes an early protest against the inhumanity of the African slave trade | |
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| 1700 |
| | | Boston merchant Samuel Sewall publishes The Selling of Joseph, a very early anti-slavery tract | |
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| 1735 |
| | | John Peter Zenger, editor of the Weekly Journal, is acquitted of libelling the governor of New York on the grounds that what he published was true | |
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| 1754 |
| | | Quaker minister John Woolman publishes the first part of Some Considerations on the Keeping of Negroes, an essay denouncing slavery | |
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| c. 1770 |
| | | The triangular trade, controlled from Liverpool, ships millions of Africans across the Atlantic as slaves | |
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